Serotonin 5-HT2Creceptors regulate anxiety-like behavior
نویسندگان
چکیده
منابع مشابه
Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice.
The brain serotonin (5-hydroxytryptamine; 5-HT) system is a powerful modulator of emotional processes and a target of medications used in the treatment of psychiatric disorders. To evaluate the contribution of serotonin 5-HT1A receptors to the regulation of these processes, we have used gene-targeting technology to generate 5-HT1A receptor-mutant mice. These animals lack functional 5-HT1A recep...
متن کاملSerotonin modulates electrosensory processing and behavior via 5-HT2-like receptors.
Efficient sensory processing of the environment is a critical function for any organism to survive and is accomplished by having neurons adapt their responses to stimuli based on behavioral context in part through neuromodulators such as serotonin (5-HT). We have recently shown that one critical function of the serotonergic system in weakly electric fish is to enhance sensory pyramidal neuron r...
متن کاملAge-Dependent Relevance of Endogenous 5-Lipoxygenase Derivatives in Anxiety-Like Behavior in Mice
When 5-lipoxygenase (5-LO) is inhibited, roughly half of the CNS effect of the prototypic endocannabinoid anandamide (AEA) is lost. Therefore, we decided to investigate whether inhibiting this enzyme would influence physiological functions classically described as being under control of the endocannabinoid system. Although 5-LO inhibition by MK-886 reduced lipoxin A4 levels in the brain, no eff...
متن کاملBlockade of 5-HT1A receptors reverses anxiety-like behavior in gonadectomized male rats
The aim of the present study was to explore the effects of 8-OH-DPAT, 5-HT1A receptor agonist and NAN-190, 5-HT1A receptor antagonist on anxiety-related behavior in the adult gonadectomized (GDX) male rats. Moreover, another goal of this work was to investigate whether the combination of 8-OH-DPAT or NAN-190 plus testosterone propionate (TP) could affect anxiety-like behavior more than TP alone...
متن کاملKnockout of 5-Lipoxygenase Results in Age-Dependent Anxiety-Like Behavior in Female Mice
BACKGROUND The enzyme 5-lipoxygenase (5LO) has been implicated in a variety of neurological and psychiatric disorders including anxiety. Knockout of 5LO has previously been shown to alter anxiety-like behavior in mice at a young age but the effect of 5LO knockout on older animals has not been characterized. METHODOLOGY/PRINCIPAL FINDINGS Here we used the elevated plus maze behavioral paradigm...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Genes, Brain and Behavior
سال: 2007
ISSN: 1601-1848,1601-183X
DOI: 10.1111/j.1601-183x.2007.00316.x